What Do You Have?
When you start looking into what can be chronic conditions for those in the world today, there are many that hadn’t been identified in times past. More than likely these negative conditions have become more prevalent with the onset of modern methods of growing, preparing and preserving foods, as well as other types of exposures that affect the human system in ways that haven’t been experienced centuries or even decades before now.
Whether you feel it’s from substances, environments, or what you may have taken in internally throughout your life, the chronic and continuous aches and pains, along with the other effects being felt by the differing syndromes, conditions and diseases, there is a need to have a daily maintenance or a “fill up” or “tune up”.
Some turn to Big Pharma with a pill for that, and another pill for this and yet still more pills for the side effects that previous pills cause… who wants to put in synthetic toxins into your system to play a form of Russian roulette with your body?
Still others try to self medicate with “legalized” substances and try to dull the symptoms being experienced. Looking to get a respite from the consistent pain or condition some even go further into the illegal or opioids and/or narcotics that only serve to addict someone with very little upside (if any could have such).
Getting It Right
When you look into it deeper, when you are sick, or feeling under the weather for an indeterminate amount of time, it is usually a sign that your body is off-balance. Something either chemical, or hormonal or something physical is not functioning properly. Fortunately there is a system in all of us that continually seeks to bring us back to a balanced state. And when that system, which is called the Endocannabinoid System (find out more here) and how it all works (more about it here) is not functioning to its full capacity then we experience and manifest the symptoms of what ails us.
Our body has what it takes to cure us. To take the actual cause of our diseases and get rid of them. Now a good portion of the time, we need the help of those knowledgeable in these areas. And we are grateful and appreciate doctors and modern medical advances. And with any condition you may have, we recommend you consult a doctor who’s job it is to diagnose what may be taking you down a peg or two.
We also encourage, in assisting them and your wonderful body in bringing it back into balance with the proper use of CBD and it’s closely-related compounds.
Here are a few things that have been found out to benefit from the use of CBD:
— The Skeletal System
The endocannabinoid system has been implicated in the regulation of bone metabolism. R
Cannabinoid ligands regulate bone mass. R
CB1 and CB2 receptors have a protective effect against age-dependent bone loss in mice. R
Administration of CBD led to improvement in fracture healing. R
Therefore CB2 agonists (like CBD) enhances endocortical osteoblast number helping osteoperosis. R
- CB1 receptor deficiency in aged mice results in accelerated age-dependent osteoporosis due to marked increase in bone resorption and significant reduction in bone formation coupled to enhanced adipocyte accumulation in the bone marrow compartment. R R
- Bone loss was also reported in CB2 deficient mice. R
- CBD stimulated mRNA expression of Plod1 in primary osteoblast cultures, encoding an enzyme that catalyzes lysine hydroxylation, which is in turn involved in collagen crosslinking and stabilization. R
- Co-expression of TRPV1, CB1/CB2, NAPE-PLD and FAAH was found in both human osteoclast cultures and in native osteoclasts from human bone biopsies. R
- Activation of CB1 in sympathetic nerve terminals in bone inhibits norepinephrine release, thus balancing the tonic sympathetic restrain of bone formation. R
- A CB2-specific agonist that does not have any psychotropic effects enhances endocortical osteoblast number and activity and restrains trabecular osteoclastogenesis, apparently by inhibiting proliferation of osteoclast precursors and receptor activator of NF-kappaB ligand expression in bone marrow-derived osteoblasts/stromal cells. R
— The Liver Functions
Ischemia/reperfusion (I/R) is a pivotal mechanism of liver damage after liver transplantation or hepatic surgery. R
CBD significantly reduced the extent of liver inflammation, oxidative/nitrative stress, and cell death. R
Myeloid-derived suppressor cells (MDSCs) are one of the main regulatory cells of the immune system. R
While MDSCs induced by CBD in liver consisted of granulocytic and monocytic subsets at a ratio of ∼2∶1, the monocytic MDSCs were more immunosuppressive compared to granulocytic MDSCs, so they may help in certain autoimmune conditions. R
Cannabidiol restores liver function, normalizes 5-HT levels and improves brain pathology in accordance with normalization of brain function. R
- CBD attenuated the bacterial endotoxin-triggered NF-κB activation and TNF-α production in isolated Kupffer cells, likewise the adhesion molecule expression in primary human liver sinusoidal endothelial cells stimulated with TNF-α and attachment of human neutrophils to the activated endothelium. R
- CBD significantly reduced the expression of inducible nitric oxide synthase, cyclooxygenase-2, nuclear factor-κB, Fas ligand and caspase-3, and increased the expression of survivin protein in ischemic/reperfused liver tissue. R
— Irritable Bowel Syndrome
Enteric glial cells (EGC) actively mediate acute and chronic inflammation in the gut. R
GC proliferate and release neurotrophins, growth factors, and pro-inflammatory cytokines. R
They can amplify the immune response, representing a very important link between the nervous and immune systems in the intestine. R
- CBD inhibits 5-HT3 receptor. R
- CBD reduced the expression of S100B and iNOS proteins. R
- Mediated via the selective PPAR-gamma R R
- Cannabinoids can affect both the activity and the expression of TRPV1-4 channels in the gastro tract. R
— Crohn’s and Colitis
- CB1 and CB2 receptors reduce the increase of intestinal motility induced by inflammatory stimuli. R
Dysfunction of the endocannabinoid system may contribute to the development of migraine attacks. R
Activation of ECS can reduce migraine attacks. R
- Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors. R
- It significantly reduced the NTG-induced neuronal activation in nucleus trigeminalis caudalis. R
- CNR1 effects migraine headaches. R
— The Heart
CBD is beneficial in the cardiovascular system. R
It protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models. R
Also, CBD has been shown to reduce infarct size and increase blood flow in animals after stroke. R
It can also normalize blood pressure. R
- AM251 suppresses arrhythmias. R
- CBD influences the survival and death of white blood cells, white blood cell migration and platelet aggregation. R
- CB1-mediated cardiodepressor and vasodilator effects of endogenous anandamideblocks its hydrolysis can normalize blood pressure. R
- Vasodilation is mediated by endothelium-derived nitric oxide, endothelium-dependent hyperpolarization, and also through activation of TRPV1 receptors. R
The Body Balance You Need
When you are truly listening to your body and what it needs to remain healthily balanced is a step in the right direction. Getting the right daily intake of nutrients, minerals, and yes CBD can bring it all back to when you felt the most healthy in your life.
Take this opportunity to get your balance back on track today!