When taking enough, it generally only takes about 20-30 minutes for it become effective.  Most people when first starting out, do not know what to expect and often overlook that it is beginning to help their condition.  Since there is no “high” to report, most people don’t know that it is doing anything.  Only after a while do they realize that any pain they may have had is no longer there or not as intense.  The “feeling” is so subtle that usually, all that is able to be identified is a subtle calming.  After several uses, many people have reported that they now notice it “taking the edge” off minutes after administering.  But, for most newcomers, they expect a huge change and its just not like that, unless it’s being used for pain management.  A gentle release of the pain is usually fairly noticeable when taking these products in proper amounts.